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Urostat-80

Dosage Form:- Tablets
Generic Name:- Febuxostat 80mg
Manufactured By:- National Healthcare Pvt. Ltd.

Information

Febuxostat is a drug that inhibits Xanthine oxidase, thus reducing production of uric acid in the body. It is used in the treatment of chronic gout and hyperuricemia


Therapeutic Class

Antihyperuricaemic Agent (Xanthine Oxidase Inhibitor)


Dose and Direction of Use

Can be taken with or without food.


Mode of Action

Uric acid is the end product of purine metabolism in humans and is generated in the cascade of hypoxanthine → xanthine → uric acid. Both steps in the above transformations are catalyzed by xanthine oxidase (XO).Febuxostat is a 2-arylthiazole derivative that achieves its therapeutic effect of decreasing serum uric acid by selectively inhibiting XO. Febuxostat has been shown to potently inhibit both the oxidized and reduced forms of XO. Thus reduces uric acid levels.


Uses

Treatment of chronic hyperuricemia in conditions where urate deposition has already occurred (including a history, or presence of, tophus and/ or gouty arthritis).


Contraindications

Febuxostat is contraindicated in patients being treated with azathioprine or mercaptopurine.

Hypersensitivity


Precautions and Warning

Treatment with febuxostat in patients with ischaemic heart disease or congestive heart failure is not recommended.

Patients should be advised of the signs and symptoms and monitored closely for symptoms of allergic/hypersensitivity reactions. Febuxostat treatment should be immediately stopped if serious allergic/hypersensitivity reactions, including Stevens-Johnson syndrome, occur since early withdrawal is associated with a better prognosis.

Febuxostat treatment should not be started until an acute attack of gout has completely subsided. Gout flares may occur during initiation of treatment due to changing serum uric acid levels resulting in mobilisation of urate from tissue deposits.If a gout flare occurs during febuxostat treatment, it should not be discontinued.

 Liver function test is recommended prior to the initiation of therapy with febuxostat and periodically thereafter.

Caution is required when febuxostat is used in patients with alteration of thyroid function


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National Healthcare Pvt. Ltd.


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