TOMAVEX
Dry Powder for Injection
Dose Type
Information
TOMAVEX is the brand name of combination of Cefoperazone 1000 mg + Sulbactam 500 mg Dry Powder for Injection. It belongs to the class of Third Generation Cephalosporin + Beta-lactamse inhibitor.
Therapeutic Class
Third Generation Cephalosporin + Beta-lactamse inhibitor
Dose and Direction of Use
Use the SWFI provided to reconstitute and the reconstituted solution must be used immediately. TOMAVEX can be given as both I.V./I.M. injection.
Mode of Action
- Cefoperazone binds with bacterial transpeptidase and inhibits the cross-linking of Peptidoglycan.
- This leads to bacterial cell wall synthesis inhibition and thus, death of the bacteria.
- However, some bacteria produce Beta-lactamase enzyme that breaks the beta-lactam ring of cefoperazone thus, making it ineffective.
- In such a scenario, Sulbactam provides its own Beta-lactam ring as a substrate for Beta-lactamase enzyme thus, saving Cefoperazone which then exerts its bactericidal activity.
Uses
- Respiratory Tract Infections (Upper and Lower)
- Urinary Tract Infections (Upper and Lower)
- Peritonitis, Septicemia, Meningitis, Endometritis
- Cholecystitis, Cholangitis
- Skin and Soft Tissue Infections
- Bone and Joint Infections
- Pelvic Inflammatory Disease
- Gonorrhea and other infections of the Genital Tract
Contraindications
- Known hypersensitivity to penicillin, cephalosporins or other components of drug
Precautions and Warning
- Use in Neonates: For neonates in the first week of life, the drug should be given every 12 hours. The maximum daily dosage of Sulbactam in pediatrics should not exceed 80 mg/kg/day.
- Use in Pregnancy: Crosses the placental barrier. This drug should be used during pregnancy only if clearly needed.
- Use in Nursing Mothers: Caution should exercised as small quantities are excreted in human milk.
- Use in Hepatic Dysfunction: Since, Cefoperazone is extensively excreted in bile dose modification is required. Daily dose of 2g/day of cefoperazone should not be exceeded.
- Use in Renal Dysfunction: Dosage Regimens of Tomavex should be adjusted in patients with marked decrease in renal function
- Use in Elderly: Dose Adjustment is necessary
