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Seroxim-500

Dosage Form:- Tablets
Generic Name:- Cefuroxime Axetil 500mg
Manufactured By:- National Healthcare Pvt. Ltd.

Information

Cefuroxime is a broad spectrum antibiotic of cephalosporin group.It is a second generation cephalosporin. It works by fighting bacteria in your body. Cefuroxime is used to treat many kinds of bacterial infections, including severe or life-threatening forms.


Therapeutic Class

Broad Spectrum Antibiotic agent


Dose and Direction of Use

Cefuroxime axetil tablets should be taken after food for optimum absorption.


Mode of Action

Cefuroxime axetil undergoes hydrolysis by esterase enzymes to the active antibiotic, cefuroxime.

Cefuroxime inhibits bacterial cell wall synthesis following attachment to penicillin binding proteins (PBPs). This results in the interruption of cell wall (peptidoglycan) biosynthesis, which leads to bacterial cell lysis and death.


Uses

- Acute streptococcal tonsillitis and pharyngitis.

- Acute bacterial sinusitis.

- Acute otitis media.

- Acute exacerbations of chronic bronchitis.

- Cystitis

- Pyelonephritis.

- Uncomplicated skin and soft tissue infections.

- Treatment of early Lyme disease.


Contraindications

Patients with known hypersensitivity to cephalosporin antibiotics.

History of severe hypersensitivity (e.g. anaphylactic reaction) to any other type of betalactam antibacterial agent (penicillins, monobactams and carbapenems).

 


Precautions and Warning

Caution should be taken when administering to individuals with a history of gastrointestinal disease, particularly colitis.

The concomitant administration of aminoglycosides and some cephalosporins has caused nephrotoxicity even though it is not recorded in case of Cefuroxime yet caution is recommended during concomitant use with aminoglycoside.

Special care is indicated in patients who have experienced an allergic reaction to penicillins or other beta-lactam antibiotics because there is a risk of cross-sensitivity.

The Jarisch-Herxheimer reaction has been seen following cefuroxime axetil treatment of Lyme disease. It results directly from the bactericidal activity of cefuroxime axetil on the causative bacteria of Lyme disease, the spirochaete Borrelia burgdorferi. Patients should be reassured that this is a common and usually self-limiting consequence of antibiotic treatment of Lyme disease

As with other antibiotics, use of cefuroxime axetil may result in the overgrowth of Candida. Prolonged use may also result in the overgrowth of other non-susceptible microorganisms (e.g. enterococci and Clostridium difficile)

The development of a positive Coomb's Test associated with the use of cefuroxime may interfere with cross matching of blood

As a false negative result may occur in the ferricyanide test, it is recommended that either the glucose oxidase or hexokinase methods are used to determine blood/plasma glucose levels in patients receiving cefuroxime axetil.


This medicine has been viewed 380 times and last modified on 2020-10-08 13:29:53

National Healthcare Pvt. Ltd.


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