(MIXAR) Rifaximin, an antibiotic, is prescribed for the treatment of hepatic encephalopathy and traveller’s diarrhoea due to Escherichia coli infections in adults and pediatric patients, 12 years and over. Unlike other antimicrobials, Rifaximin is not absorbed into the systemic circulation, and it acts specifically in the GIT. Rifaximin should not be used for the treatment of other infections. Rifaximin is also prescribed for the treatment of hepatic encephalopathy, hepatic failure and to delay worsening of brain functions.
Non-Aminoglycoside Semi-Synthetic, Non-Systemic Antibiotic.Anti-diarrheals
Dose and Direction of Use
To treat Traveller's Diarrhoea , take this medication by mouth with or without food as directed by doctor usually every 8 hours for 3 days.Finish the prescribed amount of the medication or else the infection might return.
To treat irritable bowel syndrome, take this medication by mouth with or without food as directed by doctor 3 times a day for 14 days.
To treat hepatic encephalopathy, take this medication by mouth with or without food as directed by doctor 2 times a day every 12 hours.
Mode of Action
Rifaximin is an antibacterial drug of the Rifamycin class that irreversibly binds the beta sub-unit of the bacterial enzyme DNA-dependent RNA polymerase and consequently inhibits bacterial RNA synthesis. Rifaximin has a broad antimicrobial spectrum against most of the Gram-positive and negative, aerobic and anaerobic bacteria, including ammonia producing species. Rifaximin may inhibit the division of Urea-Delaminating Bacteria, thereby reducing the production of Ammonia and other compounds that are believed to be important to the pathogenesis of Hepatic Encephalopathy.
- Irritable Bowel Syndrome with Diarrhea
- Hepatic Encephalopathy
- Traveler's Diarrhea
Rifaximin is contraindicated in patients with a Hypersensitivity to Rifaximin, any of the Rifamycin antimicrobial agents, or any of the components in Rifaximin. Don't use this medicine in such case
Precautions and Warning
- Talk to your doctor about medical history.
- Discontinue medication if condition worsen or persists >24-48 hours.
- This medication shoule be used only when needed in pregancy as discussed with doctor.
- Do not take two doses at one time.Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.