Generic Name:- Cefixime 200mg + Potassium Clavulanate 125mg
Manufactured By:- National Healthcare Pvt. Ltd.
FIXIM CV is the brand name of combination of Cefixime 200 mg + Potassium Clavulanate 125 mg Tablet. It belongs to a class of Cephalosporin + Beta-lactamse inhibitor antibiotics.
Third Generation Cephalosporin + Beta-lactamse inhibitor
Dose and Direction of Use
- To be swallowed whole with water.
- Consume after meal.
Mode of Action
- Cefixime binds with bacterial transpeptidase and inhibits the cross-linking of Peptidoglycan.
- This leads to bacterial cell wall synthesis inhibition however, resistant bacteria can cleave the beta-lactam ring of cefixime and make it ineffective.
- Potassium Clavulanate saves the beta-lactam ring of cefixime by allowing its own ring to be cleaved and prevents drug resistance.
- In this way FIXIM CV leads to cell wall synthesis inhibition of resistant bacterias.
- Uncomplicated Urinary Tract Infections (e.g. cystitis, cystourethritis, uncomplicated pyelonephritis)
- Upper Respiratory Tract Infections (URTIs) eg: otitis media, pharyngitis, tonsilitis
- Acute Exacerbations of Chronic Bronchitis
- Uncomplicated Gonorrhoea (cervical/urethral)
Hypersensitivity to Cephalosporin and Beta-lactamse inhibitor
Precautions and Warning
- Cefixime as with other broad-spectrum antibiotics should be prescribed with caution in individuals with a history of colitis.
- Increases in prothrombin times may occur and therefore care should be taken in patients receiving anticoagulant therapy.
- No adequate and well-controlled studies in pregnant women have been reported so Cefixime-Clav should therefore not be used in pregnancy or in nursing mothers unless considered essential by the physician.