Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. Etodolac is used to treat Osteoarthritis, Rheumatoid Arthritis and Acute Pain. It reduces joint pain, stiffness and swelling and helps you to do more of your normal activities.
NSAIDs, COX-2 Inhibitor
Dose and Direction of Use
Take this medication by mouth as prescribed by doctor, once daily with full glass of water. Don't lie down for at least 10 minutes after taking this medication. You can take this medication with food or milk to avoid upset stomach. Don't crush or chew this medication.
Mode of Action
Similar to other NSAIDs, the anti-inflammatory effects of etodolac result from inhibition of the enzyme cycooxygenase (COX). This decreases the synthesis of peripheral prostaglandins involved in mediating inflammation. Etodolac binds to the upper portion of the COX enzyme active site and prevents its substrate, arachidonic acid, from entering the active site. Etodolac was previously thought to be a non-selective COX inhibitor, but it is now known to be 5 – 50 times more selective for COX-2 than COX-1. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.
For acute and long-term management of signs and symptoms of osteoarthritis and rheumatoid arthritis, as well as for the management of pain.
Don't use this medicine if you have:
- Hypersensitivity to this medicine
Precautions and Warning
- Before taking this medication, tell your doctor or pharmacist about your medical history. Mainly, history of asthma or worsening of breathing due to intake of NSAIDs, blood disorders, stomach or intestinal bleeding or ulcers.
- Tell your doctor or pharmacist if you have any allergies related to NSAIDs.
- Drink plenty of fluid as told by the doctor to avoid dehydration.