Dofylin
Tablets
Dose Type
Doxofyllin 400mg
Generic Name
National Healthcare Pvt. Ltd.
Manufactured By
Information
Doxofyllin 400mg Tablet is used to treat and prevent symptoms of asthma and chronic obstructive pulmonary disorder (a lung disorder in which flow of air to the lung is blocked). It helps in relaxing the muscles of the air passages, thus widening it and making it easier to breathe.
Therapeutic Class
Methyl xanthine Derivative Bronchodilator
Dose and Direction of Use
Can be taken with or without food. More preferably with food and to be taken at the same time every day to get the most benefit.
Mode of Action
It inhibits an enzyme called phosphodiesterase thus increasing the levels of cAMP and promoting smooth muscle relaxation which results in bronchodilation (dilation or widening of the airways in the lungs by relaxing the surrounding smooth muscle).
Uses
Doxofylline is primarily indicated in conditions like Bronchial Asthma, Bronchospasm, Chronic Asthmatic Bronchitis and Chronic Obstructive Pulmonary Diseases (COPD).COPD is a lung disease characterized by chronic obstruction of lung airflow that interferes with normal breathing and is not fully reversible. It relieves the breathlessness and cough thereby providing symptomatic relief.
Contraindications
It is contraindicated in individuals with known hypersensitivity to the drug or other xanthine derivatives. It is also contraindicated in patients with acute myocardial infarction, hypotension and during lactation.
Precautions and Warning
- Numerous factors may reduce the hepatic clearance of xanthine derivatives with increased plasma levels of the drug. These factors include age, congestive cardiac decompensation, chronic obstructive pulmonary disease, severe liver disease, concomitant infections, the concurrent administration of several drugs such as: erythromycin, TAO, lincomycin, clindamycin, allopurinol, cimetidine, influenza vaccine and propranolol. In these cases, it may prove necessary to reduce the dosage of the drug.
- Phenytoin, other anticonvulsants and cigarette smoking may increase the clearance of xanthine derivatives with a reduction of plasmatic half-life. In these cases, it may prove necessary to increase the dosage of the drug. In case of factors that may influence the clearance of xanthine derivatives, monitoring of the concentration of the blood levels of the drug is recommended for the control of the therapeutic range.
- Caution should be observed in administering the product to patients with cardiac disease, hypertension, in the elderly, in patients with severe hypoxemia, hyperthyroidism, chronic cor pulmonale, congestive heart failure, liver disease, peptic ulcer and in those with renal impairment.
- In particular, it is to be used with caution in patients with congestive heart failure, since the clearance of the drug is considerably slower in these patients in which high blood levels may persist for long periods even after discontinuation of the treatment.
- There is no risk of addiction or any other form of dependence.